EVALUATION OF ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF CYATHOCLINE PURPUREA
Abstract
Peptic ulcer disease is a serious gastrointestinal disorder that requires a well targeted therapeutic strategy. A number of drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapses, side effects and drug interactions. The aim of this study to elucidate anti-ulcer activity of ethanolic extract of Cyathocline purpurea. The female albino rats were artificially induced ulcer by absolute ethanol (5 ml/kg). The animals were randomly assigned to different groups each consisting of six rats. About four groups were created. Groups III and IV received sucralfate and ethanolic extract of Cyathocline purpurea (Leaves) respectively one hour before the administration of ethanol once a day for all 15 days.The results showed that ethanolic extract of Cyathocline purpurea (EECP) has significant effect on protecting and treating gastric ulcer induced by ethanol. ethanolic extract of Cyathocline purpurea (EECP) significantly (P<0.05) reduced gastric lesions by 40.98% in ethanol induced ulcer models at 250 mg/kg when compared to sucralfate (100 mg/ kg) which reduced gastric lesions (60.41%). From the results it can be deduced that Cyathocline purpurea have effective anti- ulcer property.
Keywords: Anti -ulcer activity, Cyathocline purpurea, Medicinal plants, Sucralfate
References
Najm WI. Peptic ulcer disease. Primary Care: Clinics in Office Practice. 2011 Sep 1;38(3):383-94.
Napolitano L. Refractory peptic ulcer disease. Gastroenterology Clinics. 2009 Jun 1;38(2):267-88.
Awaad AS, El-meligy RM, Soliman GA (2013) Natural products in treatment of ulcerative colitis and peptic ulcer. J Saudi Chem Soc 17(1):101–124
Tambewagh UU, Kandhare AD, Hoore VS, Kadam PP, Khedkar VM, Bodhankar SL et al. International Immunopharmacol ogy Anti-inflammatory and antioxidant potential of Guaianolide isolated from Cyathocline purpurea. Role of COX-2 inhibition. International Immunopharmacol ogy. 2017; 52:110-8.
Ma G, Chong L, Li Z, Cheung AHT, Tattersall MHN. Anticancer activities of sesquiterpene lactones from Cyathocline purpurea in vitro, 2009, 143-52
Mukherjee PK. Quality Control of Herbal Drugs, 2nd Edition, Business Horizons, 2007; 2-14.
Kokate CK. Ed. Practical Pharmacognosy, 4th Edn., Vallabh Prakashan: 1994; 112:120.
Arpana Gaur Mishra, Richa Singh, Neha Patil, Geeta Parkhe. Determination of total phenolic, flavonoid content, antioxidant and antimicrobial activity of gloriosa superba seed extract. Asian Journal of Pharmaceutical Education and Research. 2017; 6(2):12-17.
Organization for Economic Cooperation and Development. OECD Guidelines for the Testing of Chemicals. Acute Oral Toxicity -Up-AndDown-Procedure. UDP; 425. France: OECD Publishing; 200.
Park Jh, Jang Kj, Kim Ch, Kim Jh, Kim Yk And Yoon Hm. 2015. Ganoderma lucidum pharmacopuncture for teating ethanol-induced chronic gastric ulcers in rats. J Pharmacopunc 18: 72-78.
Abebaw M, Mishra B And Gelayee Da. 2017. Evaluation of anti-ulcer activity of the leaf extract of Osyris quadripartita Decne. (Santalaceae) in rats. J Exp Pharmcol 9: 1-11.
Somani R And Singhai A. 2008. Hypoglycaemic and antidiabetic activities of seeds of Myristica fragrans in normoglycaemic and alloxan-induced diabetic rats. Asian J Exp Sci 22: 95-102.
More D, Boutagy J And Shenfield G. 1983. pH testing paper for measurement of intragastric acidity: an assessment. Anaes Intens Care 11: 147-150.
Dashputre N And Naikwade N. 2011. Evaluation of anti-ulcer activity of methanolic extract of Abutilon indicum Linn leaves in experimental rats. Int J Pharm Sci Drug Res 3:97-100.
Ozbakiş Gd And Gürsan N. 2005. Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer model in rats. Turk J Gastroentero l16: 85-88.
