Bhuvaneswari Rajachandrasekar, Dr Sakthivel vaiyapuri


Background: Schizophrenia is a chronic mental health disorder characterized by delusions, hallucinations, disorganized speech or behaviour, and impaired cognitive ability. Schizophrenia is one of the top 25 leading causes of disability worldwide. Homeopathy places great emphasis on mental health, both for treating physical and mental illnesses as a whole. We examined literature related to the potential utility of homoeopathy in treatment of schizophrenia.

Aim and objectives: The purpose of this study is to find out how effective homoeopathy is in the management of schizophrenia and also to develop a strategy for future scientific research in homoeopathy.

Materials and Methods: A systematic literature search was conducted in the international search databases (PubMed, Medscape, Google Scholar, Wiley online library, Springer, Scopus) and AYUSH portal, all relevant reviews, research articles, case series, and case reports published until 2021. We searched all keywords related to schizophrenia, analysing the study design, methodology, homoeopathic medicine prescribed, and results.

Results and Discussion: Due to limited number of literature, during the search using keywords, out of these 11 studies only six studies were evaluated for their efficacy in managing schizophrenia. These Six studies are analysed on the basis of their study design, methodology; homoeopathic medicines that was prescribed, and the results. In all these studies individualised homoeopathic medicine was given based on totality of symptoms but no common pattern of potency is followed.

Conclusion: The review illustrates the positive role of homoeopathy in treatment of schizophrenia, as the studies didn’t include any control group, their positive results should be considered preliminary. A larger number of studies on strong evidence-based parameters, with rigorous study designs including RCTs with validated scales, are essentially required to be conducted to develop evidence base of homoeopathy for schizophrenia treatment.

Keywords: Homoeopathy, Schizophrenia, Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS).

Full Text:



Mueser KT, Jeste DV, editors. Clinical handbook of schizophrenia. Guilford Press; 2011 Jan 31.

Ahuja N. A Short Textbook of Psychiatry. 7th edition. Jaypee bros Medical Publishers Pvt Ltd.

Chong HY, Teoh SL, Wu DB, Kotirum S, Chiou CF, Chaiyakunapruk N. Global economic burden of schizophrenia: a systematic review. Neuropsychiatric disease and treatment. 2016;12:35

Charlson FJ, Ferrari AJ, Santomauro DF, Diminic S, Stockings E, Scott JG, McGrath JJ, Whiteford HA. Global epidemiology and burden of schizophrenia: findings from the global burden of disease study 2016. Schizophrenia bulletin. 2018 Oct 17; 44(6):1195-203

Padmavati R., Rajkumar S, Srinivasan TN. Schizophrenic patients who were never treated – a study in an Indian urban community. Psychological Medicine 1998; 28:1113-117.

Sadock BJ, Sadock VA, Ruiz P, Kaplan &Sadock’s Synopsis of Psychiatry, Eleventh edition, Wolters Kluwer private limited New Delhi, 2018

Tsai SY, Catts VS, Fullerton JM, Corley SM, Fillman SG, Weickert CS. Nuclear receptors and neuroinflammation in schizophrenia. Molecular neuropsychiatry. 2017;3(4):181-91

Patel KR, Cherian J, Gohil K, Atkinson D. Schizophrenia: overview and treatment options. Pharmacy and Therapeutics. 2014 Sep;39(9):638.

St Clair D, Xu MQ, Wang P, Yu YQ, Fang YR,Zhang F, Zheng XY, Gu NF, Feng GY, ShamP, He L: Rates of adult schizophrenia followingprenatal exposure to the Chinese famineof 1959–1961. JAMA 2005; 294: 557–562.

Susser ES, Lin SP: Schizophrenia after prenatalexposure to the Dutch Hunger Winter of1944–1945. Arch Gen Psychiatry 1992; 49:983–988.

Schwartz PJ: Season of birth in schizophrenia:a maternal-fetal chronobiological hypothesis.Med Hypotheses 2011; 76: 785–793

Itzhaky D, Amital D, Gorden K, BogomolniA, Arnson Y, Amital H: Low serum vitamin Dconcentrations in patients with schizophrenia.Isr Med Assoc J 2012; 14: 88–92.

World Health Organization, The ICD-10, Classification of Mental and BehaviouralDisorders Diagnostic Criteria for Research, A.I.T.B.S. Publishers & Distributors, New Delhi,2004.

National Institute of Mental Health Schizophrenia 2009. Available at: schizophrenia-quadfold.pdf.Accessed June 20, 2014.

American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub; 2013 May 22.

Palmier-Claus, J.E., Taylor, P.J., Gooding, P., Dunn, G., Lewis, S.W., 2012. Affective variability predicts suicidal ideation in individuals at ultra-high risk of developing psychosis: an experience sampling study. Br. J. Clin. Psychol. 51, 72–83.

Chapman, C.L., Mullin, K., Ryan, C.J., Kuffel, A., Nielssen, O., Large, M.M., 2015. Metaanalysis of the association between suicidal ideation and later suicide among patients with either a schizophrenia spectrum psychosis or a mood disorder. ActaPsychiatr. Scand. 131, 162–173.

Kelleher, I., Ramsay, H., DeVylder, J., 2017. Psychotic experiences and suicide attempt risk in common mental disorders and borderline personality disorder. ActaPsychiatr. Scand. 135, 212–218.

Koyanagi, A., Stickley, A., Haro, J.M., 2015. Subclinical psychosis and suicidal behavior in England: findings from the 2007 Adult Psychiatric Morbidity Survey. Schizophr. Res. 168, 62–67.

Thorup A, Petersen L, Jeppesen P, Ohlenschlaeger J, Christensen T, Krarup G, Jorgensen P, Nordentoft M. Gender differences in young adults with first-episode schizophrenia spectrum disorders at baseline in the Danish OPUS study. J NervMent Dis. 2007 May;195(5):396-405. doi: 10.1097/01.nmd.0000253784.59708.dd. PMID: 17502805.

Emsley R, Chiliza B, Asmal L, Harvey BH. The nature of relapse in schizophrenia. BMC Psychiatry. 2013 Feb 8;13:50. doi: 10.1186/1471-244X-13-50. PMID: 23394123; PMCID: PMC3599855

Shaw R. The Role of Homoeopathic Medicines In The Treatment of Schizophrenia-An Analytic Report.

Balachandran VA. Homoeopathic management of schizophrenia-An analytical report

Oberai P, Gopinadhan S, Sharma A, Nayak C, Gautam K. Homoeopathic management ofSchizophrenia: A prospective, non-comparative, open-label observational study. Indian J Res Homoeopathy 2016;10:108-18.

Jayakumar M, Lalithaa KS. A Clinical Study on Paranoid Schizophrenia and Its Homoeopathic Management.

Janagam J, Mohan ND. A case report of paranoid schizophrenia treated with homoeopathy in psychiatry ward.

Gupta G. Schizophrenia and Homoeopathy: A Review. Alternative Therapies in Health and Medicine. 2021 Aug 30.


  • There are currently no refbacks.

                                                   International Journal of AYUSH (Ayurveda, Yoga, UnaniSiddha and Homeopathy)