MA’JUN SANA: AN IMPORTANT UNANI FORMULATION FOR THE MANAGEMENT OF MULTIPLE DISEASES

Authors

  • Khadija Abdul Hafiz Nationa Institute of Unani Medicine, Bengaluru
  • Davinder Kumar
  • Dr. Imran Khan
  • Kaleem Ahmad

Abstract

Background: Ma’jun Sana is an important and well known formulation of Unani System of Medicine, claimed to be effective for the management of diseases of stomach, intestine, brain and joints.

Aim of the study: To evaluate the therapeutic effect of Ma’jun Sana on the basis of pharmacological action and pharmacological studies of its ingredients.

Methodology: A bibliographic database for review of literature on Ma’jun Sana was undertaken using the viz. Pub Med, Google Scholar, Science Direct, and Scopus. The information was also collected from different books of Unani literature and conventional medical science.

Result: Ma’jun Sana & it’s ingredients have laxative & purgative property due to presence of anthraquinone glycoside whereas some ingredient has antioxidant property that strengthens the body organ & these activities are proved by different in vitro & experimental studies.

Conclusion: Ma’jun Sana has proven to be beneficial to counter the effects of constipation. So, more scientific studies and clinical trials are needed on this compound formulation to ensure its scientific validation for clinical use in patients in general and in elderly in particular.

Keyword: Ma’jun Sana; laxative; purgative; antioxidant

Author Biography

  • Khadija Abdul Hafiz, Nationa Institute of Unani Medicine, Bengaluru
    Department of Ilmul Advia (Pharmacology)

References

Mayer D. Brief History of Medicine and Statistics. Essential Evidence-Based Medicine. USA: Cambridge University Press; 2009.

Mosihuzzaman M, Chaudhary MI. Protocols on Safety, Efficacy, Standardization, and Documentation of Herbal Medicine. Pure Appl Chem 2008; 809: 2195-2230.

Hariharan P, Subburaju T. Medicinal Plants and its Standardization. A Global and Industrial Overview. Global Journal of Medicinal Plant Research 2012; 1: 10-13.

Vaidya ADB, Devasagayam TPA. Current status of herbal drugs in India, An overview. J Clin Biochem 2007; 41: 1-11.

Khan HMS. Bayaz-e-Khaas Al-Maroof Ilajul Amraz (Urdu Translation by Kabiruddin HM). New Delhi: Ejaz Publication House; 2006.

Kabiruddin. Bayaz-e-Kabeer. Part 1st. Lahore: Shaikh Mohd. Bashir & Sons; 2006.

Anonymous. Standard Unani Medical Terminology. New Delhi: Central Council for Research in Unani Medicine Department of AYUSH, Ministry of Health & Family Welfare, Government of India; 2012.

Rashid B, Zarnigar, Mohd. Younis P, Itrat M, Tarique M. Review of Majoone Falasfa-A Unani formulation. The Pharma Innovation Journal 2015; 3: 83-88.

Hafeez A. Qarabadeen Jadeed. New Delhi: CCRUM; 2005.

Unani Tibbi Conference. Qarabadeen Majeedi. 9th Ed. New Delhi: All India Unani & Tibbi Conference; 1986.

Kabiruddin HM. Al-Qarabadeen. New Delhi: CCRUM; 2006.

Ghani HN. Qarabadeen Najmul Ghani. New Delhi: CCRUM; 2010.

Arzani Ma. Qarabadeen Qadri. New Delhi: Ejaz Publications; 1998.

Said HM. Hamdard Pharmacopoeia of Eastern Medicine. Delhi: Sri Satguru Publications; 1997.

Anonymous. Standardization of single Drugs of Unani Medicine. Part1st & part 5th. New Delhi; CCRUM, Ministry of Health and Family Welfare, Department of AYUSH; 2006.

Kabeeruddin AHM. Makhzan-Ul-Mufradat. New Delhi: Idara Kitab-Us-Shifa; 2010.

Anonymous. The Unani Pharmacopoeia of India, Vol. 1st. Part 1st and part I, Vol. 3, Part 1 Vol. 2, part I, Vol. 5. New Delhi: Ministry of Health and Family Welfare, Department Of AYUSH; 2007.

Khare CP. Indian Medicinal Plants. New Delhi: Springer Private Limited; 2007.

Saeed A. Kitab Al Fatah Fi Al Tadawi (Urdu Translation). Delhi: NCPC Printers; 2007.

Abdul Hakeem HM. Bustanul Mufradat. New Delhi: Idara Kitabus Shifa; 2002.

Bagdadi IH. Kitabul Mukhtarat Fit Tib. Part. 2nd. 1st ed. New Delhi: CCRUM Ministry of Health and Family Welfare, Govt of India; 2005.

Anonymous. The Ayurvedic Pharmacopoeia of India. Vol. 1st. Part 1st.and Vol. 3. Part 1st. New Delhi: Ministry of Health and Family Welfare, Department Of AYUSH; 2001.

Bhalsing SR, Deshpande HA. Recent Advances in the Phytochemistry of Some Medicinally Important Cassia Species: A Review. Int. J. Pharm. Med. & Bio. Sc. 2013; 2: 60-78.

Ganapaty S, Thomas PS, Ramana KV, Vidyadhar K, Chakradhar V. A Review of Phytochemical Studies of Cassia Species. Journal of Natural Remedies 2002; 2: 102-20.

Ramchander, Jalwal P, Middha A. Recent advances on senna as a laxative: A comprehensive review. Journal of Pharmacognosy and Phytochemistry 2017; 6: 349-53.

Saeidi S, Bameri Z, Boroujeni NA, Bazi S. Antibacterial Activity of Cassia angustifolia Extract Against Some Human Pathogenic Bacteria. Journal of Novel Applied Sciences 2013; 2: 584-86.

Memon S, Laghari A, Nelofar A, Laghari A. Extraction, Identification and Antioxidative Properties of the Flavonoid-Rich Fractions from Leaves and Flowers of Cassia Angustifolia. American Journal of Analytical Chemistry 2011; 2: 871-78.

Mohan V, Shanmugasundaram R, Devi V, Tresina P, Maruthupandian A. Hepatoprotective Activity of Ethanol Extracts of Clitoria ternatea L. and Cassia angustifolia Vahl. Leaf Against Ccl4 Induced Liver Toxicity In Rats. International Research Journal of Pharmacy 2010; 1: 201-05.

Nanumala. SK, Nischal Y, Sarika M, Shravya GSS. Hypolipidemic activity Of Ethanolic Extracts of Cassia angustifolia in Triton- X 100 Induced Hyperlipidemia in Rats. Asian J Pharm Clin Res 2014; 7: 189-91.

Ahmed S, Zahid A, Abidi S, Meer S. Anti-Emetic Activity Of Four Species Of Genus Cassia In Chicks. IOSR Journal of Pharmacy 2012; 3: 380-84.

Multani HC. Hindustan wa Pakistan Ki Jadi Booti. Part 4. Lahore: Maktaba Daniyal; YNM.

Hakim HM. Mufradat Azeezi. New Delhi: CCRUM; 2009.

Kabeeruddin HM. Ilmul Adviya Nafeesi Ma Zameema. New Delhi: Ejaz Publishing House; 2007.

Ghani HN. Khazainul Advia. New Delhi: Idara Kitabul Shifa; YNM.

Sina I. Al-Qanoon Fit Tib. Vol. 2.nd (English translation By Dept. of Islamic Studies Jamia Hamdard). New Delhi: S. Waris Nawab, Senior Press Supreintendent; 1998.

Boskabady MH, Shafei MN, Saberi Z, Amini S. Pharmacological Effects of Rosa Damascena. Iranian Journal of Basic Medical Sciences 2011; 14: 295-07.

Kazerani HR, Arezoomandan R, Behnam-Rasooli MB. The Laxative and Prokinetic Effects of Rosa damascena Mill in Rats. Iranian Journal of Basic Medical Sciences 2010; 14:9-16.

Venkateswarlu G, Naga sudha B, Reddy YS, Kumar SV, Raghavendra HG, Kumar HMS. Evaluation of antiulcer and in-vitro antioxidant activities of Rosa damascena Mill. Asian Journal of Phytomedicine and Clinical Research 2013; 1: 167-79.

Nyeem MAB, Alam MA, Awal MA, Mostofa M, Uddin SJ, Islam N, et al. CNS Depressant Effect of the Crude Ethanolic Extract of the Flowering Tops of Rosa damascena. Iranian journal of pharmacology & therapeutics 2006; 5: 171-74.

Munawwar HK, Raza M, Zafar S. Anti-narcosis effects of essential oil of Rosa damascena mill after inhalation in rats. Journal of Environmental Research and Development 2013; 7: 1610-13.

Khaliq T, Mumtaz F, Rahman Z, Javed I, Iftikhar A. Nephroprotective Potential of Rosa damascena Mill Flowers, Cichorium intybus Linn Roots and Their Mixtures on Gentamicin-Induced Toxicity in Albino Rabbits. Pakistan Veterinary Journal 2015; 35: 43-47.

Khan MA. Muheete Aazm. Vol.3rd. New Delhi: CCRUM, Ministry of Health and Family Welfare, Govt. of India; 2014.

Baitar I. Al Jame ul Mufradat ul Advia wal Aghzia (Urdu translation). Vol. 1st. New Delhi: CCRUM, Ministry of Health and Family Welfare, Govt. of India; 1985.

Bhattacharjee PSK. Handbook of Medicinal Plants. 4th ed. Jaipur: CRC Press, Pointer Publishers; 2004.

Anonymous, The Wealth of India-A Dictionary of Indian raw Materials. Vol. 2nd, 6th, 9th, 11th. New Delhi; National Institute of Science Communication and Information Resources, Council of Scientific and Industrial Research; 2006.

Soodi M, Naghdi N, Hajimehdipoor H, Choopani S, Sahraei E. Memory-improving activity of Melissa officinalis extract in naïve and scopolamine-treated rats. Research in Pharmaceutical Sciences 2014; 9: 107-14.

Noorul Basar SN, Zaman R. An Overview of Badranjboya (Melissa officinalis). International Research Journal of Biological Sciences 2013; 2: 107-09.

Turan M. Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo. Asian Pacific Journal of Cancer Prevention 2012; 13: 2765-70.

Rastogi RP. Compendium of Indian medicinal plants. Vol-1st, 2nd, 3rd, 4th, 5th. Lucknow, New Delhi: CDRI, NISCIR; 1960-1969, 1970-1979, 1980-1984, 1985-1989, 1990-1994.

Wahid A, Hamed AN. Hepatoprotective activity of Borago officinalis extract against CCl4 induced hepatotoxicity in rats. Journal of Natural Products 2015; 8: 113-22.

Ahmad S, Singh M, Kamal YT, Khan MA, Parveen R. In Vitro Antioxidant Activity and HPTLC Analysis of Borago Officinalis Linn. Indian Journal of Pharmaceutical Education and Research 2013; 47: 24-30.

Giri M, Swamy BMV, Jayaveera KN. Evaluation of Adaptogenic Activity of Unani Herb Borago Officinalis. Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences 2013; 2: 10-15.

Anonymous. The Useful Plant of India. New Delhi; National Institute of Science Communication. 2000.

Kriticar KR, Basu MBD. Indian Medicinal Plants. Vol. 1. Dehradun: International book distributors; 2008.

Anonymous. Flora medica. 2001 ed. New Delhi: Ajay book service; 2001.

Sharma V, Agrawal RC. Glycyrrhiza glabra- a plant for the future. Mintage journal of Pharmaceutical & Medical Science 2013; 3: 15-20.

Mazumder PM, Pattnayak S, Parvani H, Sasma D, Rathinavelusamy P. Evaluation of immunomodulatory activity of Glycyrhiza glabra L. roots in combination with zing. Asian Pacific Journal of Tropical Biomedicine 2012; 15-20.

Rathi SG, Suthar M, Patel P, Bhaskar VH, Rajgor NB. In-vitro Cytotoxic Screening of Glycyrrhiza glabra L. (Fabaceae): A Natural Anticancer Drug. J Young Pharm 2009; 1: 239-43.

Mahmoudabadi AZ, Iravani M, Khazrei A. Anti-fungal activity of Glycyrrhiza glabra (Licorice) against vaginal isolates of Candida. Bio Technology an Indian Journal 2009; 3: 75-77.

Nitalikar MM, KMunde KC, Dhore BV, Shikalgar SN. Studies of Antibacterial Activities of Glycyrrhiza glabra Root Extract. International Journal of Pharm Tech 2010; 2: 899-901.

Rathi P, Rajput CS. Antioxidant Potential of Grapes (Vitis vinifera) A Review. Journal of drug delivery and therapeutics 2014; 4: 102-04.

Lucian LM, Lazar SL, Lazar M, Ciuzan O, Pamfil D. Pharmacological effects of bioactive compounds from Vitis vinifera (Grape). Pro Environment. 2015; 8: 439-44.

Ergun F, Sendogdu N, Aslam M, Orhan DD, Yesilada E. Antidiabetic and Antioxidant effects of Vitis vinifera L. Leaves in Streptozotocin Diabetic rats. Turkish J. Pharm Sci. 2006; 3: 7-18.

Ahmad W. In vitro Antibacterial Activity of Vitis vinifera leaf Extracts against some pathogenic bacterial strains. Advances in Biological Research 2014; 8: 62-67.

Asgarpanah J, Haghighat E. A Review of Phytochemistry and Meidicnal Properties of Jujube (Ziziphus vulgaris L.). Journal of Pharmaceutical and Health Sciences 2012; 1: 89-97.

Balakrishnan A, Pamaiah B. Hypoglycemic and Hypolipidemic Effects of Zizyphus jujuba Lam. In Streptozotocin-Induced Diabetic Rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences 2013; 4: 611-16.

Balakrishnan A, Balasubramaniyam PD, Natesan SK. Antipyretic Activity of Zizyphus jujube Mill. Leaves. Journal of Advanced Scientific Research 2012; 3: 40-42.

Preeti, Tripathi S. Ziziphus Jujuba: A Phytopharmacologycal Review. International Journal of Research and Development in Pharmacy and Life Sciences 2014; 3: 995-96.

Veeresh, Kambhoja S. Antihelmintic activity of Zizyphus Jujuba Mill. International Journal of Pharma and Bio Sciences 2011; 2: 508-12.

Patel AK, Pathak N, Trivedi H, Gavania M, Patel M, Panchal N. Phytopharmacological properties of Cordia dichotoma as a potential medicinal tree: an overview. International Journal of Institutional Pharmacy and Life Sciences 2011; 1: 40-51.

Sulieman AM, El-Newary SA. Hypolipidemic Effect of Cordia dichotoma Forst. Pulp in High-fat Diet-Fed Rats. World Journal of Dairy & Food Sciences 2014; 9: 260-71.

Shah D, Nitin M, Prasad K, Limbani B. Gastroprotective and antiulcer effect of Cardia dichotoma. International research journal of pharmacy 2011; 2: 70-72.

Gupta AK. Quality standards of the Indian medicinal plants. Vol. 1st. New Delhi: ICMR; 2003.

Vaibhav D, Aher, Kumar A, Wahi. Immunomodulatory effect of alcoholic extract of Terminalia chebula ripe fruits. J. Pharm. Sci. and Res 2010; 2: 539-44.

Chopra RN. Glossary of Indian Medicinal Plants. New Delhi; National Institute of Science Communication and Information Resources, CSIR; 2009.

Suresh C, Shachi S, Maurya M. Comparative laxative evaluation for Andrographis paniculata and Terminalia chebula in experimental animal model. International research journal of pharmacy 2013; 4: 167-69.

Balaji K, Ni LH, Rajindran B, Sikarwar MS, Fuloria N, Fuloria S. Determination of Total Phenolic, Flavonoid Content and Antioxidant Activity of Terminalia Chebula (Fruit). Research Journal of Pharmaceutical, Biological and Chemical Sciences 2015; 6: 413-17.

Haque MM, Jami. SI, Sultana Z, Ali ME, Begum MM. Evaluation of analgesic and anti-inflammatory activities on ethanolic extraction of Terminalia chebula fruits in experimental animal models. American journal of plant sciences 2014; 5: 63-69.

Zearah SA. Antifungal and antibacterial activity of flavonoid extract from Terminalia Chebula Retz. Fruits. Journal of Basrah Researches Sciences 2014; 40: 122-31.

Phachonpai W. Assessment of Neuropharmacological Activities of Terminalia Chebula in Rats. American Journal of Pharmacology and Toxicology 2012; 7: 41-48.

Mittal P, Gupta V, Goswami M, Thakur N, Bansal P. Phytochemical and Pharmacological Potential of Viola odorata. International journal of pharmacognosy 2015; 2: 215-20.

Ghorbani A, Mousavi SH, Naghizade B, Pourgonabadi S. Protective effect of Viola tricolor and Viola odorata extracts on serum/glucose deprivation-induced neurotoxicity role of reactive oxygen. Avicenna journal of Phytomedicine 2016; 6: 434-41.

Hassan F, Naeem I. Biological activity of Viola odorata Linn. Against Mycobacterium Tuberculosis. International Journal of Pharma and Bio Sciences 2014; 5: 61-69.

Monadi A, Rezaie A. Evaluation of Sedative and Pre-Anesthetic Effects of Viola odorata Linn. Extract Compared With Diazepam in Rats. Bulletin of Environment, Pharmacology and Life Sciences 2013; 2: 125-31.

Marwat SK, et al. Medicinal and Pharmacological Potentiality of the Plant At-Tin-Common Fig (Ficus carica L.). Asian Journal of Chemistry 2011; 23: 1-10.

Vasundhara S, Hafsa A, Rajiv G. Memory Enhancing Effects of Ficus carica leaves in Hexane extract on interoceptive Behavioral Models. Asian J Pharm Clin Res 2013; 6: 109-13.

Patil VV, Shandavi C, Bhangale, Patil VR. Studies on Immunomodulatory Activity Of Ficus Carica. Int L Pharm Sci 2010; 2: 97-99.

Askari GA. In Vitro Antimicrobial Activity Of Aqueous And Ethanolic Extracts Of Leaves Of Ficus Carica Collected From Five Different Regions Of Morocco. J. Mater. Environ. Sci 2013; 4: 33-38.

Vikas VP, Bhangale SC, Patil VR. Evaluation of anti-pyretic potential of Ficus carica leaves. International Journal of Pharmaceutical Sciences Review and Research 2010; 2: 48-50.

Dhungana P, Devi P, Borthakur SK. Pharmaceutical properties of Indian species of Ficus Linn. International Journal of Pharmacy & Life Sciences 2013; 4: 2314-2319.

Vishal A, Parveen K, Pooja S, Kannappan N, Kumard S. Diuretic, Laxative and Toxicity Studies of Viola odorata Aerial Parts. Pharmacologyonline 2009; 1: 739-748.

Oh HG, Lee HY, Seo MY, Kang YR, Kim JH, Park JW. Effects of Ficus carica paste on constipation induced by a high-protein feed and movement restriction in beagles. Lab Anim Res 2011; 27: 275-81.

Sharma V, Agrawal RC. Glycyrrhiza glabra- A plant for the future. Mintage journal of Pharmaceutical & Medical Sciences 2013; 2: 15-20.

Naftali T, Feingelernt H, Lesin Y, Rauchwarger A, Konikoff FM. Ziziphus jujuba Extract for the Treatment of Chronic Idiopathic Constipation: A Controlled Clinical Trial. Digestion 2008; 78: 224-228. DOI: 10.1159/000190975.

Malik EM, Muller CE. Anthraquinones as Pharmacological Tools and Drugs. Medicinal Research Reviews 2016; 36: 705-48. DOI 10.1002/med.21391.

Downloads

Published

2021-10-27