EXPERIMENTAL EVALUATION OF ANTI-PYRETIC ACTIVITY OF RHIZOME OF DRYNARIA QUERCIFOLIA (L.) J. SM.
Abstract
Plants are being used as a source of medicine since ancient times. But only a limited number of studies were done to explore the medicinal power of pteridophytes like Drynaria quercifolia (L.) J. Sm. Ayurvedic physicians in Kerala using its rhizome externally to cure rheumatic complaints, fissure in ano etc. Reports shows that the tribal peoples also uses its rhizome as food and medicine. Present study aimed on revalidating the medicinal property of internally administered rhizome for its antipyretic action thorough in-vivo method. Suspension of the rhizome powder was orally given to Wistar Albino rats in half the calculated effective dose (0.108gm/200gm b. Wt.), calculated effective dose (0.216gm/200gm b. Wt.) and double the calculated effective dose (0.432gm/200gm b. Wt.) and the results were analyzed using repeated measures ANNOVA with Tukey’s post hoc analysis within the groups and one way ANNOVA with Tukey’s post hoc analysis for between group. All the three treated groups shown reduction in rectal temperature but the drug administered in half the calculated effective dose shown maximum antipyretic effect at shortest time after administration that was sustainable. Study revealed dose dependent anti-pyretic activity of choorna (powder) of rhizome of Drynaria quercifolia (L.) J. Sm.
Key words: Drynaria quercifolia (L.) J. Sm., pteridophytes, rhizome, Ayurvedic, anti-pyretic
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