EFFICASY OF DIANOVA –A POLY HERBAL FORMULATION ON LIPID PROFILE IN NON- INSULIN DEPENDENT DIABETES MELLITUS PATIENTS
Abstract
This present work was undertaken to study the antihyperlipidaemic effect of Dianova a poly herbal Sidda formulation, the churanam (powder) of Dianova consist of 6 herbs, Gymnema sylvestre, Eugenia jambolana, Salasia riticulata, Curcuma longa,Terminalia chebula,& Phyllanthus embilica. All herbs have antidiabetic effect. The present study was planned to effect the clinical efficacy and safety of Dianova in the management of lipid profile in Non –insulin dependent diabetic mellitus . This was a preliminary clinical trial. A total of 10 patients of either sex, between 55- 65 years of age, in whom the diagnosis of NIDDM was confirmed, and who were willing to give informed consent were included in the study. Insulin – dependent diabetes mellitus patients and NIDDM patients with acute complications of diabetes, patients with severe hypertension and who were not willing to give informed consent were excluded in the study. Before the administration of the drug under trial initial lipid profile level was taken subsequently the lipid profile level at the end of 1st , 2nd & 3rd week following the administration of drug under trial. Dianova was administered as a dose of 3g twice daily for 3 weeks. All the patients were followed up for 3 wks. (during the treatment period). All adverse events reported or observed by patients were recorded with information about severity, date of onset, duration and action taken regarding the drug. Statistical analysis was done. This study observed a results of blood testing for lipid profile level among patient ,the prevalence of lipid profile level reduced in lipid profile level. The initial and final Cholesterol (mg/dl) values were 182+/-2. 30 and 148 +/- 2.6, Serum HDL Level (mg/ dl) 45.5 +/- 1.30 and 43.5 +/- 2.6, Serum LDL Level (mg/dl) 103 +/- 2.40 and 84 +/- 1.7 and Triglycerides Level (mg/ dl) 184 +/- 2.40 and 158+/- 2.8 , P< 0.001 respectively. The present study Dianova shows significant antihyperlipdaemic activity.
Key words:- Diabetes mellitus, Dianova., Siddha formulation, antihyperlipidaemic
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