EXPERIMENTAL EVALUATION OF ANTIPYRETIC ACTIVITY OF SEBASTIANIA CHAMAELEA (L.) MULL.ARG. (MALAYALAM NAME – KODIYAAVANAKKU)
Abstract
The drug Sebastiania chamaelea (L.) Mull.Arg of the family Euphorbiaceae is mentioned as Kodiyaavanakku in Van Rheede’s Hortus Malabaricus along with its medicinal uses. Presently there is a need to validate the local flora to meet the rising need for herbal medicines. As an initial step for the purpose the drug Sebastiania chamaelea (L.) Mull.Arg was subjected to preliminary pharmacological evaluation which includes the evaluation of antipyretic activity. Detailed literary review regarding the subject had been done. In pharmacological study, in vivo analysis of antipyretic (Brewer’s Yeast induced pyrexia) activity was done in Wistar albino rats. Animals were divided into a control group and three dose groups (effective dose, half the effective dose and double the effective dose). The choorna (powder) form of the whole plant Sebastiania chamaelea (L.) Mull.Arg (Kodiyaavanakku) was given orally to test dose groups. On statistical analysis, significant antipyretic activity was observed in each study group at p < 0.05. But this antipyretic effect was not statistically significant when compared between groups.From the statistical analysis, it can be concluded that the drug Sebastiania chamaelea (L.) Mull.Arg possess antipyretic activity.
Keywords: Sebastiania chamaelea (L.) Mull.Arg, Antipyretic activity, Brewer’s yeast injection
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