THERAPEUTIC EVALUATION OF A TOPICAL UNANI FORMULATION IN PATIENTS WITH QŪBĀ (DERMATOPHYTOSIS): A CASE SERIES
Abstract
Introduction
Qūbā (Dermatophytosis/ Ringworm) is a superficial chronic fungal infection of the skin caused by dermatophytes. It is a common cause of skin disease worldwide, especially in tropical areas. The three main genera of dermatophyte fungi that affect humans are Trichophyton, Microsporum and Epidermophyton. Tinea corporis occurs on the trunk and extremities, and usually presents with typical annular or circular lesions, vesicular or scaly, itchy papules with erythematous border and central clearing, and sometimes oozing. The diagnosis is confirmed by microscopy of skin scrapings using 10% KOH preparation or by fungal culture.
Methodology/ Case Presentation
We had four cases of Qūbā (Dermatophytosis), presenting with itching, erythema, scaling, and central clearing with peripheral raised margins of the glabrous skin. KOH mount examination of skin scraping, and haematological & biochemical investigations were performed before and after treatment. Marham Kharish Jadeed was topically applied on the skin lesions for a period of 29 to 51 days.
Discussion
After 29 to 51 days of topical application of Marham Kharish Jadeed, the symptoms and signs of Qūbā (Dermatophytosis) were subsided, and KOH mount examination became negative revealing the efficacy of the study drug. All the patients were having values of their haematological and biochemical investigations within normal limits after treatment, showing the safety of the study drug.
Conclusion
The local application of Marham Kharish Jadeed was found effective in Dermatophytosis, suggesting its antifungal activity. No adverse effects were seen during study, and no recurrence of the lesions was observed after treatment. However, further study with larger series and longer follow-up is required.
KEYWORDS: Dermatophytosis, Qūbā, Marham Kharish Jadeed, KOH mountReferences
James WD, Elston DM, Berger TG. Andrews Diseases of the Skin, 12th ed., Elsevier, 2016; pp. 285-90.
Siddappa K, et al. IADVL Textbook of Dermatology, 4th ed., Bhalani publishing house, Vol. 1, 2016, pp. 460-75.
Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ. Wolff K. Fitzpatrick’s Dermatology in General Medicine, 8th ed., McGraw Hill, 2012, 2; pp. 2278-95.
Sehgal VN. Textbook of Clinical Dermatology, 5th ed., Jaypee Brothers Medical Publishers (P) Ltd., 2011; pp. 55 - 61.
Griffiths CEM, Barker J, Bleiker T, Chalmers R, Creamer D. Rooks Textbook of Dermatology, 9th ed., Wiley Blackwell, 2016, 1; pp. 32.18-32.37.
Kasper, Fauci, Hauser, Longo, Jameson, Coscalzo. Harrison's Principles of Internal Medicine, 19th ed. McGraw Hill, Vol. 2, 2015, pp. 1357-58.
Agarwal AK, Gupta P, Kamath SA, Nadkar MY, Singal RK, et al. API Textbook of Medicine, 10th ed. Jaypee Brothers Medical Publishers (P) Ltd. 2015; pp. 1:666-68.
Firdaus S, Ali F, Sultana N. “Dermatophytosis (Qūbā) a misnomer infection and its management in modern and Unani perspective - A comparative review”, J. Med. Plants Studies, 2016; 4(2): 109-114
Tariq SH, Aleem S, Latafat T. “Clinical Evaluation of Efficacy of Majoon Ushba and Marham Gulabi in Qūbā”, IJTK, 2011; 10(4): pp. 702-705.
Ṭabarī AHAM. Mu‘ālajāt al-Buqrāṭiyya, Translation by CCRUM, New Delhi, Ministry of Health & Family Welfare, Govt. of India. Vol. 2, 1997; pp. 211-13.
Anonymous. National Formulary of Unani Medicine, 1st ed., CCRUM, Rakmo Press Pvt. Ltd., New Delhi, Vol. 5, 2008; p.116-117.
Anonymous. Qarābādīn-i Majīdī, All India Unani Tibbi Conference, Delhi, 1986; pp. 339-40.
Anonymous (2012). Standard Unani Medical Terminology. CCRUM, Dept. of AYUSH, Ministry of Health & Family Welfare, Government of India, New Delhi, p. 207.
Chaudhary G. Lawsonia inermis Linnaeus: A Phytopharmacological Review, Int. J. Pharm. Sci. Drug Res., 2010, 2 (2): 91-98.
